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Allen, J
The medication is available in escalating doses ranging from 2.5 mg to 15 mg, allowing for gradual titration to optimize efficacy while minimizing gastrointestinal side effects
The brain pathway may be more significant than the endocrine route for the physiological effects of GLP-1, especially regarding insulin release, but the endocrine route becomes more pronounced with bigger meals and more L-cell activation (Deacon 2019)
Whilst this might be therapeutically desirable in some patients, excessive or rapid weight loss requires monitoring
From a regulatory standpoint, MOTS-c is classified as a research peptide in most jurisdictions and is not FDA-approved for any indication
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